Cephalosporins: Spectrum of Activity Made Easy
Spectrum of activity:
- 1st generation: Mainly Gram+Gram – (PEcK): Proteus, E.Coli, Klebsiella
- 2nd generation: Gram- > Gram+HEN PEcKS: Haemophilus influenzae, Enterobacter, Neissera, Proteus, E. Coli, Klebsiella, Serratia
- 3rd generation: Gram – >> Gram +Ceftriaxone: Meningitis, GonorrheaCeftazidime: PseudomonasUsed to treat meningitis and sepsis (can cross Blood Brain Barrier)
- 4th generation: Pseudomonas
- 5th generation: MRSA
Cephalosporins don’t have activity against: “LAME”
Listeria
Atypicals (including Mycoplasma and Chlamydia)MRSA (Except 5th generation)
Enterococci
Atypicals (including Mycoplasma and Chlamydia)MRSA (Except 5th generation)
Enterococci
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