Cephalosporins: Spectrum of Activity Made Easy

Spectrum of activity:
  1. 1st generation: Mainly Gram+
    Gram – (PEcK): Proteus, E.Coli, Klebsiella
  2. 2nd generation: Gram- > Gram+
    HEN PEcKS: Haemophilus influenzae, Enterobacter, Neissera, Proteus, E. Coli, Klebsiella, Serratia
  3. 3rd generation: Gram – >> Gram +
    Ceftriaxone: Meningitis, GonorrheaCeftazidime: PseudomonasUsed to treat meningitis and sepsis (can cross Blood Brain Barrier)
  4. 4th generation: Pseudomonas
  5. 5th generation: MRSA
Cephalosporins don’t have activity against: “LAME”
Listeria
Atypicals (including Mycoplasma and Chlamydia)MRSA (Except 5th generation)
Enterococci

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