Cephalosporins: Spectrum of Activity Made Easy
Spectrum of activity: 1st generation: Mainly Gram+ Gram – (PEcK): Proteus, E.Coli, Klebsiella 2nd generation: Gram- > Gram+ HEN PEcKS: Haemophilus influenzae, Enterobacter, Neissera, Proteus, E. Coli, Klebsiella, Serratia 3rd generation: Gram – >> Gram + Ceftriaxone: Meningitis, Gonorrhea Ceftazidime: Pseudomonas Used to treat meningitis and sepsis (can cross Blood Brain Barrier) 4th generation: Pseudomonas 5th generation: MRSA Cephalosporins don’t have activity against: “LAME” L isteria A typicals (including Mycoplasma and Chlamydia ) M RSA (Except 5th generation) E nterococci